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KMID : 1038620120300030146
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Radiation Oncology Journal
2012 Volume.30 No. 3 p.146 ~ p.151
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The impact of beam angle confi guration of intensitymodulated radiotherapy in the hepatocellular carcinoma
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Kim Sung-Hoon
Kang Min-Kyu
Yea Ji-Woon
Kim Sung-Kyu
Choi Ji-Hoon
Oh Se-An
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Abstract
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Purpose: This treatment planning study was undertaken to evaluate the impact of beam angle configuration of intensitymodulated radiotherapy (IMRT) on the dose of the normal liver in hepatocellular carcinoma (HCC).
Materials and Methods: The computed tomography datasets of 25 patients treated with IMRT for HCC were selected. Two IMRT plans using fi ve beams were made in each patient; beams with equidistance of 72o (Plan I), and beams with a 30o angle of separation entering the body near the tumor (Plan II). Both plans were generated using the same constraints in each patient. Conformity index (CI), homogeneity index (HI), gamma index, mean dose of the normal liver (Dmean_NL), Dmean_NL difference between the two plans, and percentage normal liver volumes receiving at least 10, 20, and 30 Gy (V10, V20, and V30) were evaluated and compared.
Results: Dmean_NL, V10, and V20 were signifi cantly better for Plan II. The Dmean_NL was signifi cantly lower for peripheral (p = 0.001) and central tumors (p = 0.034). Dmean_NL differences between the two plans increased in proportion to gross tumor volume to normal liver volume ratios (p = 0.002). CI, HI, and gamma indices were not signifi cantly different for the two plans.
Conclusion: The IMRT plan based on beams with narrow separations reduced the irradiated dose of the normal liver, which would allow radiation dose escalation for HCC.
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KEYWORD
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Hepatocellular carcinoma, Intensity modulated radiation therapy, Radiation therapy
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